Choosing different shapes and sizes of beads and buttons, makes it look interesting, and draws the eye immediately.
You can use darker tile grout, that will give your frame a more compressed look, and it will bring out the lighter coloured beads.  Paying a framing shop to mat and frame a photo is very expensive, framing photo's at home is not that difficult and can save you money. 

This frame consists out of beads, buttons, pieces of broken mirror and interior crackfiller.  You can use an old toothbrush afterwards to remove the extra filler.